In the field of Assisted Reproductive Technology (ART) LyoLife™ enables the freeze-drying of sperm, oocytes, and ovarian tissue. For example, animal sperm cells can be stored at 4°C (39.2°F) or room temperature and rehydrated, maintaining DNA integrity, comparable to fresh sperm. This makes LyoLife a fully viable alternative to traditional cryobank solutions. Rehydrated cells can feasibly be used to achieve pregnancy through various forms of assisted reproductive treatments, including in vitro fertilization. These achievements make LyoLife a fully viable alternative to traditional cry-bank solutions.


Human sperm
A novel bench top device for freeze-drying sperm cells
A. Arav, Y. Natan

Human oocytes
Cryopreservation of oocytes and embryos
A. Arav

Ram sperm
High Post-Thaw Survival of Ram Sperm after Partial Freeze-Drying
A. Arav, A. Idda, S. M. Nieddu, Y. Natan, S. Ledda

Bovine oocytes
Cryopreservation of oocytes & embryos
A. Arav

Mice ovarian tissue
Unpublished research assessing freeze-drying mice ovarian tissue
Y. Natan


Market size & growth

The Assisted Reproductive Technology (ART) market is forecast to reach $38 billion by 2025, growing by 6% year-on-year

Key trends & information

The major factors driving the ART market include:

  • Increase in infertility rates (men and women) with particular surge in male infertility cases. Increase linked to:
    • Changes in lifestyle – later age of marriage and childbirth, women delaying childbirth to pursue careers, etc.
    • Increase in risks linked to infertility: obesity, stress, polycystic ovarian syndrome, STIs, and endometrial tuberculosis
  • Rising disposable income levels, especially in emerging economies, driving higher willingness to pay for infertility treatments
  • Steady development of preimplantation genetic diagnosis (PGD) is a key driver for the global assisted reproductive technology market

Several trends likely observable over the ensuing decade:

  • IVF to dominate due to growing efficacy of modern procedures, already accounting for more than 60% of the market
  • Surrogacy to grow driven by demand for assisted reproductive technology from same-sex couples
  • Asia-Pacific to experience rapid growth, with the the gradual relaxation in conservative social norms which tended to dissuade ART

Source: Global Assisted Reproductive Technology Market (2016-2025), Transparency Market Research